Serenity is really only good for debuffing enemies. In that regard, she could probably work in most teams, though I would say it's best to pair her with a more reliable DPS since her damage is very low. A better support would also enhance the team.
She does have 2 arts cards, so she could be viable with saberlot in an arts-crit team: she could provide a few extra stars for saberlot when his skills are on cooldown while also draining enemy NP and sealing their skills. Tamamo would be the best support for this kind of setup. Her NP drain will complement Serenity's, plus she's just the best arts support in general. Bear in mind though that her star generating skills are okay, but not great as far as assassins go.
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